Biochem/physiol Actions

Primary Targethuman arginine methyl transferase

Reversible: no

Product does not compete with ATP.

Target IC₅₀: 1.41 µM against human arginine methyl transferase

Cell permeable: yes

General description

A cell-permeable, xanthenyl compound that prevents mRNA-ribosome interaction and inhibits 5′-mediated/cap-dependent initiation of protein synthesis (>95% inhibition at 50 µM in in vitro translation assays using Krebs, rabbit reticulocyte, or E. coli S30 extract).

A cell-permeable, xanthenyl compound that prevents mRNA-ribosome interaction and inhibits 5'-mediated/cap-dependent initiation of protein synthesis (>95% inhibition at 50 µM in in vitro translation assays using Krebs, rabbit reticulocyte, or E. coli S30 extract).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Novac, O., et al. 2004. Nucleic Acids Res.32, 902.Tan, Y.J., et al. 2003. J. Cancer Res. Clin. Oncol.129, 437.

Packaging

25 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Warning

Toxicity: Irritant (B)